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What Is CBD?
CBD is a naturally-occurring chemical found in the Cannabis sativa plant. Cannabis is a plant genus that contains many different compounds that can have different effects on the body.
Two different cannabis plants are marijuana and hemp. THC (tetrahydrocannabinol) and CBD (cannabidiol) are two of the chemicals found in those plants. Marijuana has higher levels of THC and lower levels of CBD. In comparison, hemp has higher levels of CBD and lower levels of THC.
Unlike THC, which creates a "high" when used, CBD is not psychoactive. Therein lies the major difference.
Involvement of CBD in pain management:
CBD is emerging as a promising pharmaceutical agent to treat pain, inflammation, seizures, and anxiety without the psychoactive effects of THC. CBD exerts its pain-relieving effects through its various interactions and modulation of the endocannabinoid, inflammatory, and nociceptive (pain sensing) systems. The endocannabinoid system consists of cannabinoid receptors that interact with our own naturally occurring cannabinoids. This system is involved in regulating many functions in the body, including metabolism and appetite, mood and anxiety, and pain perception.
Our body’s endocannabinoid system is composed of three main components:
Cannabinoid receptors, namely CB1 and CB2. CB1 receptors are predominantly found in the central nervous system (CNS, the nerves attached along the spinal cord and around the brain) and are largely responsible for the cognitive and emotional effects of marijuana, as well as our perception of pain. CB2 receptors are more common in our peripheral nervous system (PNS, the outer nerves beyond the spinal cord and brain such as those in your arms and legs, although these receptors may also be found in our CNS) and in your immune cells.
Endogenous cannabinoids (the cannabinoids that your body produces)
Enzymes that facilitate the breakdown and use of cannabinoids
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Our natural endocannabinoids function on demand, meaning that when our body senses inflammation, or needs to return to homeostasis (a state of stable balance) it will release endocannabinoids that bind to cannabinoid receptors.
CBD itself does not bind to receptors but is thought to work by inducing other components of the cannabinoid system.
In fact, CBD exerts a wide array of effects on the body’s central and peripheral nervous systems, as well as the immune system. It works in conjunction with our endocannabinoid system to function in an antioxidant capacity, to decrease inflammation, and to act as an analgesic or pain reliever. CBD may even slow the progression of osteoarthritis and prevent nerve damage, according to early model studies.
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